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Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol
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نویسنده
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leung y.-m. ,wong k.-l. ,cheng k.-s. ,kuo c.-s. ,su t.-h. ,chen y.-w. ,cheng t.-h.
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منبع
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pharmacological reports - 2012 - دوره : 64 - شماره : 3 - صفحه:739 -744
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چکیده
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Background: although diphenidol has long been deployed as an anti-emetic and anti-vertigo drug,its mechanism of action remains unclear. in particular,little is known as to how diphenidol affects neuronal ion channels. recently,we showed that diphenidol blocked neuronal voltage-gated na+ channels,causing spinal blockade of motor function,proprioception and nociception in rats. in this work,we investigated whether diphenidol could also affect voltage-gated k+ and ca2+ channels. methods: electrophysiological experiments were performed to study ion channel activities in two neuronal cell lines,namely,neuroblastoma n2a cells and differentiated ng108-15 cells. results: diphenidol inhibited voltage-gated k+ channels and ca2+ channels,but did not affect store-operated ca 2+ channels. conclusion: diphenidol is a non-specific inhibitor of voltage-gated ion channels in neuronal cells. copyright © 2012 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Diphenidol; N2A cells; NG108-15 cells
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آدرس
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graduate institute of neural and cognitive sciences,china medical university,taichung 40402, Taiwan, department of anesthesiology,china medical university,taichung 40402, Taiwan, department of anesthesiology,china medical university,taichung 40402, Taiwan, graduate institute of neural and cognitive sciences,china medical university,taichung 40402, Taiwan, department of anesthesiology,china medical university,taichung 40402, Taiwan, department of physical therapy,china medical university,taichung 40402, Taiwan, department of biological sciences and technology,china medical university,taichung 40402, Taiwan
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Authors
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