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Wheel running decreases the positive reinforcing effects of heroin
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نویسنده
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smith m.a. ,pitts e.g.
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منبع
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pharmacological reports - 2012 - دوره : 64 - شماره : 4 - صفحه:960 -964
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چکیده
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Background: the purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration. methods: rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions. results: sedentary rats self-administeredmore heroin than exercising rats,and this effectwas greatest at lowandmoderate doses of heroin. conclusion: these data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin. copyright © 2012 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Heroin; Physical activity; Positive reinforcement; Rat; Self-administration
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آدرس
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department of psychology,program in neuroscience,davidson colege,davidson,nc 28035, United States, department of psychology,program in neuroscience,davidson colege,davidson,nc 28035, United States
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Authors
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