|
|
|
|
Chemical structure of phenothiazines and their biological activity
|
|
|
|
|
|
|
|
نویسنده
|
jaszczyszyn a. ,ga̧siorowski k. ,świa̧tek p. ,malinka w. ,cieślik-boczula k. ,petrus j. ,czarnik-matusewicz b.
|
|
منبع
|
pharmacological reports - 2012 - دوره : 64 - شماره : 1 - صفحه:16 -23
|
|
چکیده
|
Phenothiazines belong to the oldest,synthetic antipsychotic drugs,which do not have their precursor in the world of natural compounds. apart from their fundamental neuroleptic action connected with the dopaminergic receptors blockade,phenothiazine derivatives also exert diverse biological activities,which account for their cancer chemopreventive-effect,as: calmodulin- and protein kinase c inhibitory-actions,anti-proliferative effect,inhibition of p-glycoprotein transport function and reversion of multidrug resistance. according to literature data on relations between chemical structure of phenothiazines and their biological effects,the main directions for further chemical modifications have been established. they are provided and discussed in this review paper. copyright © 2012 by institute of pharmacology polish academy of sciences.
|
|
کلیدواژه
|
Antipsychotics; Calmodulin; Multidrug resistance; P-glycoprotein; Phenothiazine derivatives; Protein kinase C
|
|
آدرس
|
department of basic medical sciences,wrocław medical university,kochanowskiego 14,pl 51-601 wrocław, Poland, department of basic medical sciences,wrocław medical university,kochanowskiego 14,pl 51-601 wrocław, Poland, department of drug chemistry,wrocław medical university,tamka 1,pl 50-137 wrocław, Poland, department of drug chemistry,wrocław medical university,tamka 1,pl 50-137 wrocław, Poland, faculty of chemistry,university of wrocław,f. joliot curie 14,pl 50-383 wrocław, Poland, faculty of chemistry,university of wrocław,f. joliot curie 14,pl 50-383 wrocław, Poland, faculty of chemistry,university of wrocław,f. joliot curie 14,pl 50-383 wrocław, Poland
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|