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Crosstalk between contact hypersensitivity reaction and antidepressant drugs
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نویسنده
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curzytek k. ,kubera m. ,szczepanik m. ,basta-kaim a. ,leoekiewicz m. ,budziszewska b. ,lasoñ w. ,maes m.
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منبع
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pharmacological reports - 2013 - دوره : 65 - شماره : 6 - صفحه:1673 -1680
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چکیده
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Allergic contact dermatitis is a delayed-type hypersensitivity reaction mediated by hapten-specific t cells. many cell types,inflammatory mediators and cytokines are involved in this reaction. contact hypersensitivity is a self-limited reaction and can be regulated at different levels. because it is known that disturbances in the immune system underpin the onset of depression and that antidepressant drugs have immunomodulatory effects,it can be hypothesized that antidepressants may have some efficacy in the treatment of contact hypersensitivity. there are some reports on the effectiveness of antidepressants in the inhibition of cutaneous sensitization in mice,and the aim of this narrative review is to assess the evidence for the effectiveness of antidepressant drugs in reducing the recurrence of contact hypersensitivity reactions. copyright © 2013 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Antidepressant drugs; Contact hypersensitivity; Cytokines; Depression; Desipramine; Fluoxetine
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آدرس
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department of experimental neuroendocrinology,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of experimental neuroendocrinology,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of medical biology,jagiellonian university medical college,kopernika 12,pl 31-034 kraków, Poland, department of experimental neuroendocrinology,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of experimental neuroendocrinology,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of experimental neuroendocrinology,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków,poland,department of toxicology,jagiellonian university medical college,medyczna 9,pl 30-688 kraków, Poland, department of experimental neuroendocrinology,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków,poland,institute of public health,jagiellonian university medical college,grzegórzecka 20,pl 31-531 kraków, Poland, maes clinics and tria,998 rimklongsamsen road,bangkok 10310, Thailand
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Authors
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