Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats

Background: inflammatory bowel disease (ibd) is a chronic inflammatory condition of gastrointestinal tract of immune,genetic and environmental origin. in the present study,we examined the effect of sesamol (ses),the main anti-oxidative constituent of sesamum indicum (sesame seed) linn. in the dinitrochlorobenzene (dncb)-induced model for ibd in rats. methods: the groups were divided into normal control,dncb control,ses and sulfasalazine (ss). on day 24,the rats were killed,colon removed and the macroscopic,biochemical and histopathological evaluations were performed. results: the levels of mpo,tbars and nitrite increased significantly (p < 0.05) in the dncb group,whereas reduced significantly in the ses,ss treated groups. serum nitrite levels were found to be insignificant between the different groups. il-6 and tnf-α levels were significantly high in the dncb group. conclusions:we conclude the mucosal protective effect of seson colon due to its potent antioxidant actions. further investigation is required in a chronic model of different rodent strain for its role involved in the cytokine pathway. copyright © 2013 by institute of pharmacology polish academy of sciences.