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Effect of cyclophosphamide and morin-5'-sulfonic acid sodium salt,alone or in combination,on ADMA/DDAH pathway in rats
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نویسنده
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merwid-la̧d a. ,trocha m. ,chlebda-sieragowska e. ,sozański t. ,magdalan j. ,ksia̧dzyna d. ,szuba a. ,kopacz m. ,kuźniar a. ,nowak d. ,pieśniewska m. ,fereniec-gołȩbiewska l. ,szel a.
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منبع
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pharmacological reports - 2013 - دوره : 65 - شماره : 1 - صفحه:201 -207
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چکیده
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Background: the aim of the study was to evaluate the effect of cyclophosphamide (cpx) and morin-5'-sulfonic acid sodium salt (namsa) on plasma asymmetric dimethylarginine (adma) level and dimethylarginine dimethylaminohydrolase (ddah) activity in rat liver. methods: the study was performed onwistar rats receiving normal saline,cpx (15 mg/kg/day),namsa(100 mg/kg/day) or both cpx and namsa for 10 consecutive days. results: significant decrease in admalevel was found in all groups when compared to the control. ddah activity in the liver was significantly higher in cx group compared to the control group. conclusion: obtained results of adma/ddah pathway parameters require further research. copyright © 2013 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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ADMA; Cyclophosphamide; DDAH; Morin-5'-sulfonic acid sodium salt (NaMSA); Rats
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آدرس
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department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department and clinic of internal medicine and occupational diseases,and hypertension,wroclaw medical university,pasteura 4,pl 50-367 worcław, Poland, department of inorganic and analytical chemistry,chemical faculty,rzeszow university of technology,powstańców warszawy 6,pl 35-959 rzeszów, Poland, department of inorganic and analytical chemistry,chemical faculty,rzeszow university of technology,powstańców warszawy 6,pl 35-959 rzeszów, Poland, department of inorganic and analytical chemistry,chemical faculty,rzeszow university of technology,powstańców warszawy 6,pl 35-959 rzeszów, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland, department of pharmacology,wroclaw medical university,mikulicza-radeckiego 2,pl 50-345 worcław, Poland
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Authors
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