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Influence of zinc hydroaspartate on the anti-inflammatory and gastric activity of ketoprofen in rats
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نویسنده
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gawel m. ,librowski t. ,lipkowska a.
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منبع
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pharmacological reports - 2013 - دوره : 65 - شماره : 1 - صفحه:214 -219
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چکیده
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Background: the study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (zha,60 mg/kg). methods: antiedematous activity was determined according towinter et al.,analgesic activity according to the randall and selitto test,the influence on gastric mucosa in accordance to komatsu. results: single and subchronic administration of zha and single ketoprofen po caused a significant reduction of the rat hind paw edema in comparison to the control groups. zhaalone administrated ip four times was active after the 1st,2nd and 3rd h from the carrageenan injection. conclusions: zha enhanced the anti-inflammatory effect of ketoprofen. copyright © 2013 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Anti-inflammatory activity; Antiedematous activity; Gastric ulcer healing; Non-steroidal anti-inflammatory drugs; Zinc hydroaspartate
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آدرس
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department of radioligands,medical college,jagiellonian university,medyczna 9,pl 30-688 kraków, Poland, department of radioligands,medical college,jagiellonian university,medyczna 9,pl 30-688 kraków, Poland, department of radioligands,medical college,jagiellonian university,medyczna 9,pl 30-688 kraków, Poland
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Authors
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