Effect of metformin on selected parameters of hemostasis in fenofibrate-treated patients with impaired glucose tolerance

Background: no previous study has assessed whether the addition of metformin potentiates fibrate action on hemostasis in prediabetic subjects. methods: our study included 41 fenofibrate-treated patients with impaired glucose tolerance allocated to either metformin (3 g daily) or placebo. results: twelve-week treatment with fenofibrate and metformin reduced plasma levels of fibrinogen and pai-1 and tended to change the other hemostatic markers measured,as well as improved insulin sensitivity. conclusions: our results show that high-dose metformin exhibits beneficial effects on coagulation and fibrinolysis in isolated igt patients treated with a fibrate. copyright © 2013 by institute of pharmacology polish academy of sciences.