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Eplerenone promotes alternative activation in human monocyte-derived macrophages
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نویسنده
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łabuzek k. ,liber s. ,bułdak l. ,machnik g. ,liber j. ,okopień b.
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منبع
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pharmacological reports - 2013 - دوره : 65 - شماره : 1 - صفحه:226 -234
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چکیده
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Background: in this study,we have analyzed the response of human monocyte-derived macrophages to mineralocorticoid axis modulators. methods: human monocyte-derived macrophages were incubated with aldosterone alone,eplerenone alone,and the combination of aldosterone and eplerenone. the analyzed variables were nitric oxide and reactive oxygen species production,and the gene and protein expression of inducible nitric oxide synthase,arginase i,and mannose receptor. results:we showed that aldosterone promotes a classic inflammatory response in macrophages,whereas its antagonist,eplerenone,attenuates aldosterone-induced activity. conclusion: eplerenone did not quantitatively weaken the response of macrophages to aldosterone but instead qualitatively changed their behavior. copyright © 2013 by institute of pharmacology polish academy of sciences.
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کلیدواژه
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Aldosterone; Alternative activation; Eplerenone; Human macrophages; Mineralocorticoid receptor
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آدرس
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department of internal medicine and clinical pharmacology,medical university of silesia,medyków 18,pl 40-752 katowice, Poland, department of internal medicine and clinical pharmacology,medical university of silesia,medyków 18,pl 40-752 katowice, Poland, department of internal medicine and clinical pharmacology,medical university of silesia,medyków 18,pl 40-752 katowice, Poland, department of internal medicine and clinical pharmacology,medical university of silesia,medyków 18,pl 40-752 katowice, Poland, department of internal medicine and clinical pharmacology,medical university of silesia,medyków 18,pl 40-752 katowice, Poland, department of internal medicine and clinical pharmacology,medical university of silesia,medyków 18,pl 40-752 katowice, Poland
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Authors
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