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Vitamin D and the central nervous system
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نویسنده
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wrzosek m. ,lukaszkiewicz j. ,wrzosek m. ,jakubczyk a. ,matsumoto h. ,piatkiewicz p. ,radziwon-zaleska m. ,wojnar m. ,nowicka g.
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منبع
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pharmacological reports - 2013 - دوره : 65 - شماره : 2 - صفحه:271 -278
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چکیده
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Vitamin d is formed in human epithelial cells via photochemical synthesis and is also acquired from dietary sources. the so-called classical effect of this vitamin involves the regulation of calcium homeostasis and bone metabolism. apart from this,non-classical effects of vitamin d have recently gained renewed attention. one important yet little known of the numerous functions of vitamin d is the regulation of nervous system development and function. the neuroprotective effect of vitamin d is associated with its influence on neurotrophin production and release,neuromediator synthesis,intracellular calcium homeostasis,and prevention of oxidative damage to nervous tissue. clinical studies suggest that vitamin d deficiency may lead to an increased risk of disease of the central nervous system (cns),particularly schizophrenia and multiple sclerosis. adequate intake of vitamin d during pregnancy and the neonatal period seems to be crucial in terms of prevention of these diseases. copyright © 2013 by institute of pharmacology.
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کلیدواژه
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Central nervous system; Vitamin D
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آدرس
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department of pharmacogenomics,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of biochemistry and clinical chemistry,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of internal medicine and diabetology,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of psychiatry,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of psychiatry,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of internal medicine and diabetology,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of psychiatry,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland, department of psychiatry,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa,poland,department of psychiatry,university of michigan,4250 plymouth rd.,ann arbor,mi 48109, United States, department of pharmacogenomics,medical university of warsaw,zwirki i wigury 61,pl 02-091 warszawa, Poland
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Authors
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