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Gender-dependent activity of CYP3A is indirectly modified by GR in the noradrenergic system
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نویسنده
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kot m. ,kreiner g. ,chmielarz p. ,kuoemierczyk j. ,nalepa i. ,daniel w.a.
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منبع
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pharmacological reports - 2013 - دوره : 65 - شماره : 5 - صفحه:1431 -1434
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چکیده
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Background: the noradrenergic system is involved in the regulation of cytochrome p450 activity in the liver.we investigated the effect of selective ablation of the glucocorticoid receptor in the noradrenergic systemon the activity of thecyp3aisoforminmouse liver. methods: the activity of cyp3a was studied by measuring the rate of testosterone 6b-hydroxylation in liver microsomes. results: in mutant mice,the activity of cyp3a was reduced to 68% of the control in females,but remained unchanged in males. chronic restraint stress increased cyp3a activity in mutant mice only. conclusions: the total basal activity of mouse cyp3amay be indirectly modulated by the glucocorticoid receptor in the noradrenergic system during a pubertal period. copyright © 2013 by institute of pharmacology polish academy.
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کلیدواژه
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CYP3A; Glucocorticoid receptor; Mouse gender; Noradrenaline
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آدرس
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department of pharmacokinetics and drug metabolism,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of brain biochemistry,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland, department of pharmacokinetics and drug metabolism,institute of pharmacology,polish academy of sciences,smêtna 12,pl 31-343 kraków, Poland
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Authors
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