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An anti-immobility effect of spermine in the forced swim test in mice
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نویسنده
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wośko s. ,serefko a. ,socała k. ,szewczyk b. ,wróbel a. ,nowak g. ,wlaź p. ,poleszak e.
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منبع
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pharmacological reports - 2014 - دوره : 66 - شماره : 2 - صفحه:223 -227
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چکیده
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Background: spermine is one of the naturally occurring ligands that influence the function of the nmethyl- d-aspartate receptor. similar to other endogenous polyamines present in micromolar concentration in the brain,it may play a role in the modulation of depression. thus,the present study investigated the suggested antidepressant effect of spermine. methods: the mouse forced swim test (fst) was used as a reliable tool that allowed us to determine the antidepressant activity. results: spermine,administered intracerebroventricularly (icv),significantly and dose-dependently reduced the immobility time in the fst within the dose range of 5-20 μg without changing the spontaneous locomotor activity. the pre-treatment of the animals with ifenprodil (an antagonist of the polyamine binding site of the nmda receptor),given intraperitoneally at a dose of 20 mg/kg,thoroughly reversed the anti-immobility effect of spermine (5 μg,icv). conclusion: our preliminary study revealed the anti-immobility activity of centrally administered spermine in the fst in mice,with a probable involvement of the polyamine-binding site at the nmda receptor complex. © 2014 institute of pharmacology,polish academy of sciences. published by elsevier urban & partner sp. z o.o. all rights reserved.
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کلیدواژه
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Anti-immobility effect; Forced swimming test; Mice; NMDA receptors; Spermine
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آدرس
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department of applied pharmacy,medical university of lublin,lublin, Poland, department of applied pharmacy,medical university of lublin,lublin, Poland, department of animal physiology,institute of biology and biochemistry,maria curie-skłodowska university,lublin, Poland, department of neurobiology,institute of pharmacology,polish academy of sciences,kraków, Poland, second department of gynecology,medical university of lublin,lublin, Poland, department of neurobiology,institute of pharmacology,polish academy of sciences,kraków,poland,department of pharmacobiology,jagiellonian university,medical college,kraków, Poland, department of animal physiology,institute of biology and biochemistry,maria curie-skłodowska university,lublin, Poland, department of applied pharmacy,medical university of lublin,lublin, Poland
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Authors
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