The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis

Background: the studies aimed to evaluate the changes in cysteine sulfur metabolism in erythrocytes of end-stage renal failure (esrf) patients treated with continuous ambulatory peritoneal dialysis (capd) caused by a one-month lipoate (la) supplementation at a daily dose of 600 mg. methods: the level of sulfane sulfur and activity of sulfurtransferases were determined in erythrocytes of capd patients and in the control group. results: the sulfane sulfur level in erythrocytes of capd patients did not differ compared with healthy volunteers but la supplementation increased the reactive sulfur concentration. la elevated also cystathionase activity. conclusions: la supplementation in esrf patients treated with capd increases the sulfane sulfur level which indicates the augmentation of its antioxidant and regulatory properties. © 2014 institute of pharmacology,polish academy of sciences. published by elsevier urban & partner sp. z o.o. all rights reserved.