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Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65,Akt and MAPK pathway in THP-1 cells
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نویسنده
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gao m.-y. ,chen l. ,yang l. ,yu x. ,kou j.-p. ,yu b.-y.
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منبع
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pharmacological reports - 2014 - دوره : 66 - شماره : 3 - صفحه:480 -484
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چکیده
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Background considering the key role of tf in coagulation of sepsis or acute lung injury (ali),we investigated whether berberine (bbr) could inhibit tf expression and procoagulant activity and explored its possible mechanism. methods the effects of berberine on the expression,procoagulant activity of tf and related signal pathways induced by lipopolysaccharide (lps) were observed in thp-1 cells. results our results showed that berberine could inhibit lps-induced tf activity and expression,and down-regulate nf-κb,akt and mapk/jnk/p38/erk pathways. conclusion berberine inhibits tf expression and related pathway,which provides some new insights on its mechanism for sepsis treatment. © 2014 institute of pharmacology,polish academy of sciences. all rights reserved.
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کلیدواژه
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Acute lung injury (ALI); Berberine; Mitogen-activated protein kinases; Nuclear factor (NF)-κB; Tissue factor (TF)
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آدرس
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state key laboratory of natural medicines,department of complex prescription of traditional chinese medicine,china pharmaceutical university,nanjing, China, state key laboratory of natural medicines,department of complex prescription of traditional chinese medicine,china pharmaceutical university,nanjing, China, state key laboratory of natural medicines,department of complex prescription of traditional chinese medicine,china pharmaceutical university,nanjing, China, state key laboratory of natural medicines,department of complex prescription of traditional chinese medicine,china pharmaceutical university,nanjing, China, state key laboratory of natural medicines,department of complex prescription of traditional chinese medicine,china pharmaceutical university,nanjing, China, state key laboratory of natural medicines,department of complex prescription of traditional chinese medicine,china pharmaceutical university,nanjing, China
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Authors
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