The effects of celiprolol on serum concentrations of proinflammatory cytokines in hypertensive (SHR) and normotensive (WKY) rats

A growing body of evidence suggests that some cardiovascular drugs could modulate the level of proinflammatory cytokines. therefore,the aim of the present study was to investigate whether celiprolol,a third generation β-adrenoceptor blocker,affects lipopolysaccharide (lps)-induced serum concentrations of tnf-α,il-1β,il-6 in normotensive (wky) and spontaneously hypertensive (shr) rats. methods: celiprolol (150 mg kg -1) or vehicle was administered by gavage once daily for 21 days. arterial blood pressure was measured in conscious rats,using the tail-cuff method. serum concentrations of proinflammatory cytokines were measured with enzyme-linked immunosorbent assay kits. addition-ally,plasma concentrations of total cholesterol,hdl-cholesterol and triglycerides were evaluated. results: in normotensive wky rats celiprolol did not affect heart rate,blood pressure,or the serum concentrations of triglycerides,total cholesterol or hdl-cholesterol. in hypertensive animals the drug decreased lipid parameters,increased diastolic and mean blood pressure after the first week of administration,and produced a small but significant decrease in heart rate after the first two weeks of the treatment. in both groups of animals,celiprolol decreased lps-stimulated serum concentration of il- 6 but did not affect levels of tnf-α and il-1β. conclusions: it is suggested that the il-6-modulating properties of celiprolol could provide additional value to the therapeutic effectiveness of the drug in the treatment of hypertension. © 2014 institute of pharmacology,polish academy of sciences. published by elsevier urban & partner sp. z o.o. all rights reserved.