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Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
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نویسنده
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zavala-tecuapetla c. ,kubová h. ,otáhal j. ,tsenov g. ,mareš p.
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منبع
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pharmacological reports - 2014 - دوره : 66 - شماره : 5 - صفحه:927 -930
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چکیده
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Action of an antagonist of metabotropic glutamate receptors subtype 5 mtep was studied in a model of complex partial seizures. dorsal hippocampus of rat pups 12,18 and 25 days old was stimulated six times with 10-min intervals. mtep (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. mtep exhibited marked anticonvulsant action in 12-day-old-rats,the similar effect in 18-day-old rats was observed only with the second stimulation. no anticonvulsant action was seen in 25-day-old animals. our results may qualify antagonists of mglur5 as potential antiepileptic drugs for some types of childhood epilepsies. © 2014 institute of pharmacology,polish academy of sciences. published by elsevier urban & partner sp. z o.o. all rights reserved.
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کلیدواژه
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Epileptic afterdischarge; Hippocampus; Metabotropic glutamate receptor 5; Ontogeny; Rat
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آدرس
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department of developmental epileptology,institute of physiology,academy of sciences of the czech republic,prague 4, Czech Republic, department of developmental epileptology,institute of physiology,academy of sciences of the czech republic,prague 4, Czech Republic, department of developmental epileptology,institute of physiology,academy of sciences of the czech republic,prague 4, Czech Republic, department of developmental epileptology,institute of physiology,academy of sciences of the czech republic,prague 4, Czech Republic, department of developmental epileptology,institute of physiology,academy of sciences of the czech republic,prague 4, Czech Republic
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Authors
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