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Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats
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نویسنده
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gaweł m. ,lipkowska a. ,herman m. ,golasik m. ,piekoszewski w. ,gomolka e. ,schlegel-zawadzka m. ,opoka w. ,nowak g. ,librowski t.
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منبع
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pharmacological reports - 2014 - دوره : 66 - شماره : 5 - صفحه:862 -866
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چکیده
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Background the previous study indicated the enhancement of the anti-inflammatory effect of ketoprofen by acute and sub chronic administration of zinc hydroaspartate. methods the present study examined anti-inflammatory,anti-ulcerogenic and analgesic activity induced by chronic (14 days) administration of zha (30 mg/kg,po),with a combination of a single administration of ketoprofen,in rats. moreover,the zinc concentration in serum and stomach mucosa was also determined. results chronic zha po administration exhibits anti-inflammatory activity and enhanced the effect induced by ketoprofen. likewise,zha administration demonstrated anti-ulcerogenic activity. while zha alone did not exhibit analgesic action,it enhanced the effect of ketoprofen. conclusions the present study demonstrated for the first time that chronic treatment with zinc salt exhibits anti-inflammatory activity. besides,anti-ulcerogenic activity and the enhancing properties of zinc to ketoprofen induced anti-inflammatory and analgesic activity were also shown. © 2014 institute of pharmacology,polish academy of sciences.
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کلیدواژه
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Analgesic activity; Anti-inflammatory-; Anti-ulcerogenic-; Chronic; Zinc hydroaspartate
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آدرس
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department of radioligands,jagiellonian university,medical college,kraków, Poland, department of radioligands,jagiellonian university,medical college,kraków, Poland, department of analytical chemistry,faculty of chemistry,jagiellonian university,kraków, Poland, department of analytical chemistry,faculty of chemistry,jagiellonian university,kraków, Poland, department of analytical chemistry,faculty of chemistry,jagiellonian university,kraków,poland,laboratory of high resolution mass spectrometry,faculty of chemistry,jagiellonian university,kraków, Poland, laboratory of analytical toxicology and therapeutic drug monitoring,jagiellonian university,medical college,kraków, Poland, department of human nutrition,jagiellonian university,medical college,kraków, Poland, department of inorganic chemistry,jagiellonian university,medical college,kraków, Poland, department of cytobiology,jagiellonian university,medical college,kraków,poland,institute of pharmacology,polish academy of sciences,center of excellence in neuropsychopharmacology,kraków, Poland, department of radioligands,jagiellonian university,medical college,kraków, Poland
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Authors
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