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Involvement of PKA,PKC,CAMK-II and MEK1/2 in the acute antidepressant-like effect of creatine in mice
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نویسنده
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cunha m.p. ,budni j. ,pazini f.l. ,oliveira á. ,rosa j.m. ,lopes m.w. ,leal r.b. ,rodrigues a.l.s.
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منبع
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pharmacological reports - 2014 - دوره : 66 - شماره : 4 - صفحه:653 -659
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چکیده
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Background the aim of this study was to investigate the involvement of signaling pathways on the creatine antidepressant-like effect in the tail suspension test (tst) in mice. methods the tst was used to assess the antidepressant-like properties of creatine. results the anti-immobility effect of creatine (1 mg/kg,p.o.) in the tst was blocked by i.c.v. pretreatment with h-89 (1 μg/site,pka inhibitor),kn-62 (1 μg/site,camk-ii inhibitor),chelerythrine (1 μg/site,pkc inhibitor),u0126 (5 μg/site,mek1/2 inhibitor) or pd09058 (5 μg/site,mek1/2 inhibitor). conclusion these results suggest that the antidepressant-like effect of creatine is dependent on pka,camk-ii,pkc and mek 1/2 activation. © 2014 institute of pharmacology,polish academy of sciences.
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کلیدواژه
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Antidepressant; Creatine; Intracellular signaling; Kinases; Tail suspension test
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آدرس
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department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil, department of biochemistry,universidade federal de santa catarina,florianópolis, Brazil
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Authors
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