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Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives
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نویسنده
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sapa j. ,zygmunt m. ,kulig k. ,malawska b. ,dudek m. ,filipek b. ,bednarski m. ,kusak a. ,nowak g.
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منبع
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pharmacological reports - 2014 - دوره : 66 - شماره : 4 - صفحه:708 -711
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چکیده
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Background the aim of this study was to examine the anticonvulsant activity of some novel pyrrolidin-2-one derivatives with considerable affinity to serotonin 5-ht1a and α1-adrenergic receptors. methods the maximal electroshock-induced seizure (mes) and pentetrazole (ptz)-induced seizure models in mice were performed. results as a results of the conducted studies,three compounds showing anticonvulsant activity were selected. the ep-40 molecule significantly reduced incidence of seizures in the maximal electroshock test. the ep-42 and ep-46 compounds demonstrated activity in the pentetrazole-induced seizures. conclusion the results may indicate that the decrease in the susceptibility to seizures induced by the new pyrrolidin-2-one derivatives is related to the significant affinity to serotonergic or α1-adrenergic receptors. also putative mechanism of action of the test compounds can be linked with their gaba-ergic activity,because these novel derivatives are gaba analogs.© 2014 published by elsevier urban and partner sp. z o.o. on behalf of institute of pharmacology,polish academy of sciences.
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کلیدواژه
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Anticonvulsant activity; Epilepsy; Pyrrolidin-2-one derivatives
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آدرس
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department of pharmacological screening,medical college,jagiellonian university,krakow, Poland, department of pharmacological screening,medical college,jagiellonian university,krakow, Poland, department of physicochemical drug analysis,medical college,jagiellonian university,krakow, Poland, department of physicochemical drug analysis,medical college,jagiellonian university,krakow, Poland, department of pharmacodynamics,jagiellonian university,medical college,krakow, Poland, department of pharmacodynamics,jagiellonian university,medical college,krakow, Poland, department of pharmacological screening,medical college,jagiellonian university,krakow, Poland, department of pharmacological screening,medical college,jagiellonian university,krakow, Poland, department of pharmacobiology,jagiellonian university,medical college,krakow,poland,department of neurobiology,institute of pharmacology,polish academy of sciences,krakow, Poland
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Authors
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