Impact of aliskiren on some hemostatic parameters in experimental arterial thrombosis in rats

Background aliskiren (al) is the first orally active inhibitor of renin to be approved for clinical use as an antihypertensive agent. a number of studies show a link between aliskiren and intravascular thrombosis.materials and methods the goal of the present study was to investigate the impact of aliskiren on arterial thrombosis in normotensive and renovascular hypertensive rats. the contribution of each coagulation and fibrinolytic parameters in the mode of aliskiren action was determined. six weeks after clipping of the left renal artery rats developed hypertension which was confirmed by the tail cuff method. animals were treated with aliskiren (10,30 and 100 mg/kg/day) per os for 10 days. arterial thrombosis was induced by electrical stimulation of the common carotid artery.results it was found that aliskiren in a dose-dependent manner decreased weight of the arterial thrombus in normotensive and hypertensive rats. it has been shown that this result was not associated with the effects on blood pressure,tf,pt,aptt,fibrinogen and hematological parameters. it was found that aliskiren caused increase of t-pa activity and decrease of its inhibitor activity.conclusions the presented results indicate that aliskiren inhibits hemostasis in the arterial thrombosis in rats. the antithrombotic effect is related with improvement of the fibrinolytic balance,and also depends on antiplatelet action. © 2014 institute of pharmacology,polish academy of sciences. © 2014 institute of pharmacology,polish academy of sciences. all rights reserved.