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Synthesis and anticancer activity of 7-hydroxycoumarinyl gallates
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نویسنده
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hejchman e. ,taciak p. ,kowalski s. ,maciejewska d. ,czajkowska a. ,borowska j. ,͆ladowski d. ,młynarczuk-biały i.
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منبع
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pharmacological reports - 2015 - دوره : 67 - شماره : 2 - صفحه:236 -244
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چکیده
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Background the search for anti-cancer agents includes naturally occurring substances and theirs modifications. therefore we invented and designed compounds that represent fused derivatives of gallic acid with coumarins.methods as a result,a series of 8 novel esters of gallic acid and 7-hydroxycoumarins were synthesized and evaluated for anticancer activity. the structures of the compounds were established by ir,1h,13c nmr and hr ms spectra. the esters were assayed for antiproliferative activity against human leukemia hl-60 and prostate cancer du145 cell lines. the activity of novel esters was evaluated by cell viability assays as well as by analysis of cell cycle and cell death mechanism.results the esters were found to be of similar or higher activity than gallic acid. no pronounced harmful effect was observed in non-cancer cells.conclusions the novel compounds represent an excellent starting point for the further optimization and the design of therapeutically effective anti-cancerous drugs. © 2014 institute of pharmacology,polish academy of sciences.
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کلیدواژه
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Anticancer activity; Apoptosis; Cell cycle; Coumarin derivatives; Gallates
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آدرس
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department of organic chemistry,faculty of pharmacy,medical university of warsaw,warsaw, Poland, department of organic chemistry,faculty of pharmacy,medical university of warsaw,warsaw,poland,department of drug chemistry,faculty of pharmacy,medical university of warsaw,warsaw, Poland, department of histology and embryology,center for biostructure research,medical university of warsaw,warsaw, Poland, department of organic chemistry,faculty of pharmacy,medical university of warsaw,warsaw, Poland, department of histology and embryology,center for biostructure research,medical university of warsaw,warsaw, Poland, department of histology and embryology,center for biostructure research,medical university of warsaw,warsaw, Poland, department of transplantology and central tissue bank,center for biostructure research,medical university of warsaw,warsaw, Poland, department of histology and embryology,center for biostructure research,medical university of warsaw,warsaw, Poland
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Authors
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