Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial

Background: opioid-induced cough during induction of general anesthesia is a common phenomenon. dezocine,a partial μ-receptors agonist and κ-receptors antagonist,has been documented effectively suppressing fentanyl-induced cough in general anesthesia induction. however,the effect of dezocine on sufentanil-induced cough is still unknown. methods: a total of 370 patients (american society of anesthesiologists physical status i-ii),aged 18-70 years,undergoing elective surgery,were randomly divided into a control group (group c) and a dezocine group (group d) (n = 185 in each group). patients received dezocine 0.1 mg/kg or an equal volume of 0.9% normal saline 2 min prior to intravenous sufentanil (0.5 μg/kg). the incidence and reflex degree of cough in patients were evaluated within 2 min after the injection of sufentanil in anesthesia induction period. results: no patient in group d had cough and 59 patients in group c had cough (severity of cough: mild,7%; moderate,11.4%; severe,13.5%). the occurrence and reflex degree of cough in group d was significantly lower than that in group c (p = 0.000). the highest heart rate (hr) and invasive blood pressure (ibp) values were higher in group c than those in group d (p < 0.01) within 2 min after sufentanil administration,althought these values remained within safe limits. conclusion: the results of current study suggest that administration of dezocine 0.1 mg/kg may effectively prevent the occurrence and reflex degree of sufentanil-induced irritating cough in general anesthesia induction in patients. © 2014 institute of pharmacology,polish academy of sciences. published by elsevier urban & partner sp. z o.o. all rights reserved.