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Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes - Limitations,progress,and perspectives
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نویسنده
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debowska k. ,debski d. ,hardy m. ,jakubowska m. ,kalyanaraman b. ,marcinek a. ,michalski r. ,michalowski b. ,ouari o. ,sikora a. ,smulik r. ,zielonka j.
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منبع
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pharmacological reports - 2015 - دوره : 67 - شماره : 4 - صفحه:756 -764
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چکیده
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Over the last 40 years,there has been tremendous progress in understanding the biological reactions of reactive oxygen species (ros) and reactive nitrogen species (rns). it is widely accepted that the generation of ros and rns is involved in physiological and pathophysiological processes. to understand the role of ros and rns in a variety of pathologies,the specific detection of ros and rns is fundamental. unfortunately,the intracellular detection and quantitation of ros and rns remains a challenge. in this short review,we have focused on the mechanistic and quantitative aspects of their detection with the use of selected fluorogenic probes. the challenges,limitations and perspectives of these methods are discussed. © 2015 institute of pharmacology,polish academy of sciences. published by elsevier sp. z o.o. all rights reserved.
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کلیدواژه
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Fluorogenic probes; Hydrogen peroxide; Peroxynitrite; Protein hydroperoxides; Superoxide radical anion
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آدرس
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institute of applied radiation chemistry,lodz university of technology,łódź, Poland, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, aix-marseille université,cnrs,icr umr 7273,srep,centre de saint jérôme,marseille cedex 20, France, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, department of biophysics,free radical research center,medical college of wisconsin,milwaukee, United States, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, aix-marseille université,cnrs,icr umr 7273,srep,centre de saint jérôme,marseille cedex 20, France, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, institute of applied radiation chemistry,lodz university of technology,łódź, Poland, department of biophysics,free radical research center,medical college of wisconsin,milwaukee, United States
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Authors
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