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Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice
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نویسنده
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poleszak e. ,szopa a. ,wyska e. ,kukuła-koch w. ,serefko a. ,wos̈ko s. ,bogatko k. ,wróbel a. ,wlaź p.
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منبع
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pharmacological reports - 2016 - دوره : 68 - شماره : 1 - صفحه:56 -61
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چکیده
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Background the main goal of this research was an evaluation of the influence of caffeine on the activity of mianserin and agomelatine. methods the mouse forced swim test and tail suspension test were used to determine the influence of caffeine on the activity of the tested drugs. drug concentrations in serum and brains were estimated by hplc. results caffeine increases the anti-immobility action of mianserin and agomelatine. the observed effects were not associated with changes in the level of drugs in serum or brains. conclusion the synergistic effect of caffeine and the tested drugs may be associated with their summative actions on monoaminergic neurotransmission. caffeine-mianserin and caffeine-agomelatine interactions might have been of pharmacodynamic origin. © 2015 institute of pharmacology,polish academy of sciences.all rights reserved.
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کلیدواژه
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Antidepressant drugs; Caffeine; Forced swim test; Mice; Tail suspension test
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آدرس
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department of applied pharmacy,medical university of lublin,lublin, Poland, department of applied pharmacy,medical university of lublin,lublin, Poland, department of pharmacokinetics and physical pharmacy,collegium medicum,jagiellonian university,kraków, Poland, department of pharmacognosy with medicinal plant unit,medical university of lublin,lublin, Poland, department of applied pharmacy,medical university of lublin,lublin, Poland, department of applied pharmacy,medical university of lublin,lublin, Poland, department of applied pharmacy,medical university of lublin,lublin, Poland, second department of gynecology,medical university of lublin,lublin, Poland, department of animal physiology,institute of biology and biochemistry,faculty of biology and biotechnology,maria curie-skłodowska university,lublin, Poland
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Authors
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