Clinical efficacy and safety of eperisone for low back pain: A systematic literature review

Eperisone,an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (lbp). the present systematic review evaluates the efficacy and safety of eperisone in patients with lbp. cochrane back and neck (cbn) group and preferred reporting items for systematic reviews and meta-analyses (prisma) guidelines were adopted to perform this systematic review. for risk of bias assessment cbn group and moga tools were used. seven (5 randomized controlled trials [rcts] and 2 uncontrolled studies) studies involving 801 participants were included. eperisone intervention may be effective in acute lbp patients with less adverse effects (relative risk,0.25; 95% confidence interval,0.15-0.41; p < 0.0001). eperisone also improved paraspinal blood flow and was found to have efficacy similar to tizanidine in chronic lbp patients. the included studies in this review are of smaller sample size and short duration to support eperisone use in lbp. however,we recommend well-designed rcts of high quality with larger sample size and longer follow-up to confirm the clinical benefits of eperisone in the treatment of acute or chronic lbp. © 2016 institute of pharmacology,polish academy of sciences. published by elsevier sp. z o.o. all rights reserved.