Hyaluronan oligosaccharides promote diabetic wound healing by increasing angiogenesis

Background hyaluronan (also known as hyaluronic acid) oligosaccharides (o-ha) can promote angiogenesis and wound healing; however,there are few reports on whether o-ha also plays a role in healing wounds of diabetic patients. methods in this study,we prepared a special ointment containing a mixture of hyaluronan fragments from 2 to 10 disaccharide units and investigated its effects on healing the wounds of diabetic rats. results we found that o-ha significantly increases proliferation,migration,and tube formation of endothelial cells under high glucose conditions,and topical administration of o-ha ointment promotes wound healing by increasing angiogenesis in the wounded area of the skin. the underlying mechanisms are that o-ha increases the phosphorylation of src and erk,and expression of tgf beta1,thereby increasing angiogenesis. conclusions this suggests that topical application of o-ha could be a useful method by which to treat diabetic wounds in clinical practice. © 2016