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2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia,neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation
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نویسنده
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godin a.m. ,araújo d.p. ,menezes r.r. ,de brito a.m.s. ,melo i.s.f. ,coura g.m.e. ,bastos l.f.s. ,amaral f.a. ,teixeira m.m. ,de fátima â. ,coelho m.m. ,machado r.r.
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منبع
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pharmacological reports - 2017 - دوره : 69 - شماره : 4 - صفحه:691 -695
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چکیده
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Background phthalimide analogs have been shown to exhibit anti-inflammatory,analgesic and immunomodulatory activities in different preclinical assays. this study aimed to investigate the potential role of 2-phthalimidethanol (ptd-oh) and 2-phthalimidethyl nitrate (ptd-no) in a murine model of antigen-induced articular inflammation. methods articular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mbsa) in the knee joint of immunized male c57bl/6j mice. the animals were pre-treated with ptd-oh or ptd-no (500 mg/kg,per os,– 1 h). nociceptive threshold was measured using an electronic von frey apparatus. the total number of leukocytes in the synovial cavity was determined. concentrations of tumor necrosis factor (tnf)-α and cxcl-1 and myeloperoxidase (mpo) activity were determined in periarticular tissue. results both ptd-oh and ptd-no inhibited at similar extent the mechanical allodynia,neutrophil recruitment to the synovial cavity and periarticular tissue and tnf-α and cxcl-1 production induced by intra-articular challenge with mbsa in immunized mice. conclusions ptd-oh and ptd-no exhibit a marked activity in a murine model of antigen-induced articular inflammation in immunized animals. these results reinforce the interest in the investigation of phthalimide analogs devoid of the glutarimide ring as candidates to analgesic and anti-inflammatory drugs. © 2017
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کلیدواژه
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2-Phthalimidethanol; 2-Phthalimidethyl nitrate; Inflammation; Pain; Phthalimide analogs
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آدرس
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departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de química,instituto de ciências exatas,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de bioquímica e imunologia,instituto de ciências biológicas,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de bioquímica e imunologia,instituto de ciências biológicas,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de química,instituto de ciências exatas,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil, departamento de produtos farmacêuticos,faculdade de farmácia,universidade federal de minas gerais,belo horizonte,mg, Brazil
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Authors
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