Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats

Background fluoxetine-induced liver damage is a cause of chronic liver disease. in the present study the hepatoprotective effects of gallic acid against fluoxetine-induced liver damage were examined. methods forty-eight male rats were divided into six groups as follow: group 1,the control group; group 2,rats receiving fluoxetine (24 mg/kg bw daily,po) without treatment; group 3,rats receiving 24 mg/kg bw fluoxetine,treated with 50 mg/kg bw silymarin and groups 4,5,and 6 in which gallic acid (50,100,and 200 mg/kg bw,po,respectively) was prescribed after the consumption of fluoxetine. the histopathological changes of hepatic tissues were checked out. results fluoxetine caused a significant increase in the levels of serum glutamate oxaloacetate transaminase (got),serum glutamate pyruvate transaminase (gpt),lipid profiles,urea,fasting blood sugar (fbs),creatinine (cr),protein carbonyl (pc) content,malondialdehyde (mda),and liver tnf-α as an inflammatory element. also,the obtained results of group 2 revealed a significant decline in ferric reducing ability of plasma (frap),liver catalase (cat),superoxide dismutase (sod),and vitamin c levels. the treatment with gallic acid showed significant ameliorations in abnormalities of fluoxetine-induced liver injury as represented by the improvement of hepatic cat,sod activities,vitamin c levels,serum biochemical parameters,and histopathological changes,in addition to the recovery of antioxidant defense system status. conclusions gallic acid has inhibitory effects on fluoxetine-induced liver damage. the effect of gallic acid is derived from free radical scavenging properties and the anti-inflammatory effect related to tnf-α. © 2017