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Autophagy,mitophagy and apoptotic gene changes in the hippocampal CA1 area in a rat ischemic model of Alzheimer's disease
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نویسنده
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ułamek-kozioł m. ,kocki j. ,bogucka-kocka a. ,januszewski s. ,bogucki j. ,czuczwar s.j. ,pluta r.
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منبع
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pharmacological reports - 2017 - دوره : 69 - شماره : 6 - صفحه:1289 -1294
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چکیده
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Background postichemic brain injury correlates with poor prognosis since selectively vulnerable parts of brain are associated with apoptotic neuronal death. but autophagy has been recognized,as a probable survival mechanism following brain ischemia. methods we have analyzed,by quantitative reverse-transcriptase pcr assay protocol,three genes: autophagy,mitophagy and caspase 3 for neuronal death response in ischemic hippocampal ca1 area. results we have found that autophagy gene was not significantly modified at all time points after ischemia,whereas mitophagy and caspase 3 genes were upregulated at day 2 and decreased to basal values at days 7 and 30. conclusion it may be inferred that mitophagy process markedly accompanies apoptosis during delayed neuronal death in hippocampal ca1 area following brain ischemia. © 2017 institute of pharmacology,polish academy of sciences
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کلیدواژه
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Alzheimer's disease; Brain ischemia; Delayed neuronal death; Genes; Hippocampal CA1 area
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آدرس
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first department of neurology,institute of psychiatry and neurology,warszawa,poland,laboratory of ischemic and neurodegenerative brain research,mossakowski medical research centre,polish academy of sciences,warszawa, Poland, department of clinical genetics,medical university of lublin,lublin, Poland, department of biology and genetics,medical university of lublin,lublin, Poland, laboratory of ischemic and neurodegenerative brain research,mossakowski medical research centre,polish academy of sciences,warszawa, Poland, department of clinical genetics,medical university of lublin,lublin, Poland, department of pathophysiology,medical university of lublin,lublin,poland,department of physiopathology,institute of rural health,lublin, Poland, laboratory of ischemic and neurodegenerative brain research,mossakowski medical research centre,polish academy of sciences,warszawa, Poland
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Authors
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