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rhubarb attenuates cerebral edema via inhibition of the extracellular signal-regulated kinase pathway following traumatic brain injury in rats
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نویسنده
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yang z. ,fan r. ,sun p. ,cui h. ,peng w. ,luo j. ,zhang c. ,xiong x. ,huang w. ,liu w.
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منبع
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pharmacognosy magazine - 2018 - دوره : 14 - شماره : 53 - صفحه:134 -139
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چکیده
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Background: rhubarb is a traditional chinese medicine for treating traumatic brain injury (tbi). purpose: the purpose of this study is to elucidate the potential mechanism of rhubarb by suppressing extracellular signal-regulated kinase (erk) to ameliorate brain edema. materials and methods: sprague-dawley rats were separated into four groups at random. one group received 3 g/kg rhubarb, and another group received 12 g/kg rhubarb, and the vehicle group and sham group were administered the same dose of saline solution. the blood-brain barrier disruption and edema were detected by evans blue extravasation and water content, respectively. erk, matrix metalloproteinase 9 (mmp-9), and zonula occluden-1 (zo-1) in the damaged tissue were measured by western blot analysis and quantitative real-time polymerase chain reaction. results: rhubarb attenuated the brain edema after tbi, especially at the dose of 12 g/kg. rhubarb significantly suppressed erk, down-regulated mmp-9, and up-regulated zo-1. rhubarb might be a prospective therapeutic regimen to decrease edema in tbi. conclusions: rhubarb alleviates the edema by restraining the erk signaling pathway. our results contribute to the validation of the traditional use of rhubarb in the treatment of tbi and its mechanism.
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کلیدواژه
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brain edema ,extracellular signal-regulated kinase ,rhubarb ,traditional chinese medicine ,traumatic brain injury
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آدرس
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central south university, xiangya hospital, department of integrated traditional chinese medicine, china, central south university, xiangya hospital, department of integrated traditional chinese medicine, china, ministry of education, shangdong university of traditional chinese medicine, department of key laboratory of traditional chinese medicine for classical theory, china, central south university, xiangya hospital, department of integrated traditional chinese medicine, china, central south university, xiangya hospital, department of integrated traditional chinese and western medicine, china, central south university, xiangya hospital, department of integrated traditional chinese medicine, china, central south university, xiangya hospital, department of integrated traditional chinese medicine, china, central south university, xiangya hospital, department of integrated traditional chinese medicine, china, central south university, xiangya hospital, department of integrated traditional chinese medicine, china, central south university, xiangya hosipital, department of cardiovascular surgery, china
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Authors
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