A New Latent Lovastatin Producer viz. Fusarium pseudocircinatum IBRL B3-4, Produced in Laboratory Tray System

A proximate analysis study of local rice bran and brown rice disclosed a distinguish level of chemical compositions. lipid, carbohydrate and ash occupy in rice bran, while fibre is a predominant component in brown rice. both perceptible anti-cholesterol substrates were grown with locally isolated fusarium pseudocircinatum ibrl b3-4 to obtain the best lovastatin activity via dichloromethane extraction. evaluation of lovastatin production at different substrate thickness ranges of 0.25 to 1.5 cm in a static tray system (20x20x6 cm3) exposed the highest production at 0.5 cm level (1135.0±6.7 μg/g dry solid of lovastatin). meanwhile, effects of physical parameters investigation interpreted that the original substrate size, 60% (v/w) moisture content and ambient local temperature of 30±2°c as the most suitable conditions to generate lovastatin at the utmost level. meanwhile, the maximum production was synthesized at day 12th (twelfth) under solid substrate fermentation system. a significant activity increment was revealed after 60 % (v/v) moisture content had been applied into tray system. in more specific, it boosted up to 2271.7±14.4 μg/g dry solid of lovastatin.