Effects of Exercise and Dietary Polyunsaturated Fatty Acid on Blood Lipid Profiles of Streptozotocin-induced Diabetes in Rats

The efficacy of exercise and dietary polyunsaturated fatty acid (pufa) on streptozotocin-induced diabetes in rats was investigated based on blood lipid profiles, with respect to triglycerides, total cholesterol, high-density lipoprotein (hdl)-cholesterol, and low-density lipoprotein (ldl)-cholesterol. a total of 32 sprague-dawley male rats were used and divided into eight groups. four groups were exercised daily for 8 weeks, while the other four were sedentary. treatment diets were defined as follows: rat chow diet only (control diet), rat chow added with 2:1, menhaden oil:soybean oil (diet 1), rat chow added with 1:2, menhaden oil:soybean oil (diet 2), and rat chow added with 10% (w/w) butter (diet 3). blood plasma was collected at the end of 8 weeks for blood lipid profiles determination. the results showed that a combination of exercise and dietary pufa significantly improved lipid abnormalities by lowering the triglycerides, total cholesterol, and ldl-cholesterol levels