Evaluation Effects of Quercetin on Liver Apoptosis in Streptozotocininduced Diabetic Rat

Quercetin is a strong antioxidant and long-term treatment of stzdiabeticanimals and it has been shown to reduce oxidative stress.objective: antioxidants have essential effect on spermatogenesis and spermparameters. enhanced oxidative stress and changes in antioxidant capacity areconsidered to play an important role in the pathogenesis of chronic diabetes mellitus.methods: wistar male rat (n=40) were allocated into three groups, control group (n=10)and quercetin (qr) group that received 15mg/kg (ip) qr, (n=10), and diabetic groupthat received 55mg/kg (ip) streptozotocin (stz) (n=20) which was subdivided to twogroups of 10; stz group and treatment group. treatment group received 55mg/kg (ip)stz plus15mg/kg qr, daily for,4 weeks, respectively; however, the control group justreceived an equal volume of distilled water daily(ip) . diabetes was induced by a single(ip) injection of streptozotocin (55mg/kg) .animals were kept in standard condition. in28day after inducing diabetic 5cc blood were collected for tac,mda and ox-ldl levelsand liver tissues of rat in whole groups were removed then prepared for apoptosisanalysis by tunel method.results: apoptotic cells significantly decreased in group that has received 15mg/kg (ip)quercetin (p<0.05) in comparison to experimental groups (p<0.05).conclusion: since in our study 15mg/kg (ip) quercetin have significantly preventiveeffect on liver cells damages by reducing number of apoptotic cells in liver, so it seemsthat using it can be effective for treatment in diabetic rat.