Protective Effects of Quercetin on Spermatogenesis in Streptozotocininduced Diabetic Rat

Quercetin is a strong antioxidant and long-term treatment of stzdiabeticanimals and it has been shown to reduce oxidative stress.objective: antioxidants have essential effect on spermatogenesis and sperm parameters.enhanced oxidative stress and changes in antioxidant capacity are considered to play animportant role in the pathogenesis of chronic diabetes mellitus.methods: wistar male rat (n=40) were allocated into three groups, control group (n=10)and quercetin (qr) group that received 15mg/kg (ip) qr, (n=10), and diabetic groupthat received 55 mg/kg (ip) streptozotocin (stz) (n=20) which was subdivided to twogroups of 10; stz group and treatment group. treatment group received 55 mg/kg (ip)stz plus15mg/kg qr, daily for,4 weeks, respectively; however, the control group justreceived an equal volume of distilled water daily (ip). diabetes was induced by a singleintra peritonea injection of streptozotocin (55 mg/kg). animals were kept in standardcondition. in 28day after inducing diabetic 5cc blood were collected for testosterone,tac, mda and ox-ldl levels and testes tissues of rat in whole groups were removedand sperm was collected from epididymis then prepared for analysis.results: sperm population, percentage of sperm viability and motility significantlyincreased in group that has received 15 mg/kg (ip) quercetin (p<0.05) in comparison tocontrol and experimental groups.conclusion: since in our study 15 mg/kg (ip) quercetin have significantly preventiveeffect on sperm percentage of viability and motility by reducing level of reactive oxygenspecies (ros) in serum, so it seems that using it can be effective for sperm healthyparameters in diabetic rat.