the effect of herbal combination therapy compared to pharmaceutical treatment on hormonal changes, ovarian cysts, hirsutism, and hair loss in patients with pcos

Background: polycystic ovary syndrome (pcos) is the most common cause of anovulation and one of the main causes of infertility. management varies with emphasis on the role of herbal medicines in the treatment of polycystic ovary syndrome (pcos) compared to medical therapy. objective: the aim of this study is to compare the herbal regimen vitex agnus-castus var. + foeniculum vulgare mill. +portula caoleracea l) with a medical regimen (spironolactone + cyproterone acetate with ethinyl estradiol) in polycystic ovarian syndrome patients. method: the clinical trial, which compared two groups of women with polycystic ovary syndrome (pcos), included 64 participants aged 18 to 42 years, all referred to a gynecological clinic. in a clinical study, the division of patients into case and control groups using random assignment so that both groups are as similar as possible. the control group receives a medical regimen that is compared to the herbal regimen of the case group. results: the study did not show any statistically significant difference in follicle-stimulating hormone (fsh), thyroid-stimulating hormone (tsh), or dehydroepiandrosterone sulfate (dhea-s) levels between the control and case groups after the intervention (p > 0.05). the lh level has declined significantly after the intervention in the case group is a common finding in this research (p = 0.001). the severity or existence of hirsutism (excessive hair growth in androgen-dependent areas of the female body) did not vary significantly between the two groups being compared (p> 0.05). the case group showed a significant reduction in the rate of hair loss (p = 0.001).ovarian ultrasound showed formation of dominant follicles in case and control groups. conclusion: the herbal regimen was as effective as the phamacological regimen. vitex agnus-castus and fennel, known for their phytoestrogenic properties, induce negative feedback of luteinizing hormone with long-term use, leading to decrease in testosterone production. the synergistic effect of vitax agnus-castus, fennel and purslane combination reduce testosterone levels and accelerates the treatment of pcos.