evaluation analgesic and anti-inflammatory effects of rosa×damascena herrm. fixed oil (persian medicine preparation)

Background: historical medical and pharmacological manuscripts describe various pharmaceutical applications of medieval persian medicine. one of the known forms of application for therapeutic purposes via topical or systemic administration is herbal oils. “rose fixed oil” (rosa×damascena herrm.) has traditional applications in the management of inflammation and pain due to ailment conditions such as inflammatory bowel disease, hemorrhoid, earache, and gastro-esophageal reflux diseases topically or orally. objective: this study evaluated mechanism of analgesic and anti-inflammatory effects of “rose fixed oil” by animal models. methods: 50 grams of dried powdered petals of r.×damascena were weighed and soaked with 800ml distilled water for 24 hours. the mixture was heated for 70 minutes. writhing, tail flick, hot plate, and carrageenan tests were used for the evaluation of the anti-inflammatory and analgesic effects of rose oil. the level of tnf-α and mpo activity in serum was measured. results: “rose fixed oil” 400mg/kg in all tests have been shown a significant effect. “rose fixed oil” could decrease tnf-α and mpo. previous studies demonstrated rose extract can inhibit inflammation in animal models and clinical trials. “rose fixed oil” in some studies has been shown an anti-inflammatory effect. the results of this study confirmed anti-inflammatory and analgesic effects of “rose fixed oil” as a persian medicine preparation. conclusion: the main finding of this study was that “rose fixed oil” as a persian medicine preparation, possesses analgesic and anti-inflammatory effects through peripheral and central analgesic activity, and modulation of acute and chronic inflammation mediators in a dose-dependent manner.