some aspects of the adaptogenic potential of european mistletoe (viscum album l.) extracts under variable physical performance

Background: stress is an integral part of human life and leads to maladaptation of the organism and needs rational pharmacological correction. objective: the purpose of this experiment was to evaluate the adaptogenic potential of european mistletoe extracts. methods: the work was performed on balb/c mice. the testobjects were ethanol and aqueous extracts of european mistletoe (viscum album l., santalaceae) collected from pear and black poplar in dose 100 mg/kg (p.o.). physical overloads were modeled in the forced swimming test. the analyzed parameters were: the duration of animals swimming, changes in the parameters of mitochondrial respiration, the concentration of atp, activity of caspase3, and apoptosisinducing factor in the muscles and lactic acid in the blood serum of animals. the state of the pro / antioxidant system and acute toxicity of the testextracts was also evaluated. results: the study found that the ld50 of the testextracts was more than 5000 mg/kg (p.o.). ethanol extracts (40 and 70 %) with a single administration had the greatest impact on the physical strain of mice. in the course administration of 40 % ethanol mistletoe extracts the swimming time of mice was increased by 3.4 and 5.05 times(p < 0.05) from black poplar and pear, respectively. also, the use of 40 % extracts contributed to the normalization of the pro/antioxidant balance, the restoration of the cell energy metabolism, and the decrease of the intensity of the apoptotic reactions. conclusion: the study showed that the 40 % ethanol extracts from european mistletoe (host plants: pear and black poplar) potentially can be used as adaptogenic agents.

Some aspects of the adaptogenic potential of European mistletoe (Viscum album L.) extracts under variable physical performance

Background: Stress is an integral part of human life and leads to maladaptation of the organism and needs rational pharmacological correction. Objective: The purpose of this experiment was to evaluate the adaptogenic potential of European mistletoe extracts. Methods: The work was performed on Balb/c mice. The testobjects were ethanol and aqueous extracts of European mistletoe (Viscum album L., Santalaceae) collected from pear and black poplar in dose 100 mg/kg (P.O.). Physical overloads were modeled in the forced swimming test. The analyzed parameters were: the duration of animals swimming, changes in the parameters of mitochondrial respiration, the concentration of ATP, activity of caspase3, and apoptosisinducing factor in the muscles and lactic acid in the blood serum of animals. The state of the pro / antioxidant system and acute toxicity of the testextracts was also evaluated. Results: The study found that the LD50 of the testextracts was more than 5000 mg/kg (P.O.). Ethanol extracts (40 and 70 %) with a single administration had the greatest impact on the physical strain of mice. In the course administration of 40 % ethanol mistletoe extracts the swimming time of mice was increased by 3.4 and 5.05 times(P < 0.05) from black poplar and pear, respectively. Also, the use of 40 % extracts contributed to the normalization of the pro/antioxidant balance, the restoration of the cell energy metabolism, and the decrease of the intensity of the apoptotic reactions. Conclusion: The study showed that the 40 % ethanol extracts from European mistletoe (host plants: pear and black poplar) potentially can be used as adaptogenic agents.