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anti-acanthamoeba effect of camellia sinensis extract (black and green tea) in vitro
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نویسنده
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hajihossein reza ,eslamirad zahra ,rafiei fatemeh ,naderi gholamreza ,assadi morteza
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منبع
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journal of medicinal plants - 2020 - دوره : 19 - شماره : 73 - صفحه:163 -169
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چکیده
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Background: acanthamoeba is a resistant protozoan that causes severe diseases, such as gae and cak. because many medications are ineffective on the parasite, the quest to find alternative drugs is in progress. objective: this research was aim ed to assess the performance of the black and green tea extracts on acanthamoeba. methods: the clinical isolate of acanthamoeba was cultured on nonnutrient agar plates. the black and green tea extracts were prepared via maceration, dried by rotary evaporation, and stored at 4 °c. the main component of the extracts (caffeine) was recognized using gc-ms analysis. the effects of three concentrations of black and green tea extracts were evaluated on the parasite and compared with the control and current drug. results: black and green tea extracts have lethal effects on acanthamoeba cysts and the performance was more than that shown by the control and the current antikeratitis drug. moreover, the effectiveness of the tea extracts was tim e and dosedependent (p < 0.0001). there was no significant differences between the performance of black and green tea (p > 0.05). conclusion: black and green tea extracts demonstrated the potential to inhibit the acanthamoeba parasite, but the use of tea extract in clinical applications requires further study.
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کلیدواژه
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acanthamoeba ,camellia sinensis ,black tea ,green tea ,complementary therapy ,traditional medicine
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آدرس
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arak university of medical sciences, school of medicine, department of parasitology and mycology, iran, arak university of medical sciences, school of medicine, department of parasitology and mycology, iran, arak university of medical sciences, school of medicine, department of biostatistics, iran, islamic azad university arak branch, department of agriculture and natural resources, iran, islamic azad university tehran branch, department of biochemistry, iran
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Anti-Acanthamoeba effect of Camellia sinensis extract (black and green tea) in vitro
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Authors
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Hajihossein Reza ,Eslamirad Zahra ,Rafiei Fatemeh ,Naderi Gholamreza ,Assadi Morteza
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Abstract
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Background: Acanthamoeba is a resistant protozoan that causes severe diseases, such as GAE and CAK. Because many medications are ineffective on the parasite, the quest to find alternative drugs is in progress. Objective: This research was aim ed to assess the performance of the black and green tea extracts on Acanthamoeba. Methods: The clinical isolate of Acanthamoeba was cultured on nonnutrient agar plates. The black and green tea extracts were prepared via maceration, dried by rotary evaporation, and stored at 4 °C. The main component of the extracts (caffeine) was recognized using GCMS analysis. The effects of three concentrations of black and green tea extracts were evaluated on the parasite and compared with the control and current drug. Results: Black and green tea extracts have lethal effects on Acanthamoeba cysts and the performance was more than that shown by the control and the current antikeratitis drug. Moreover, the effectiveness of the tea extracts was tim e and dosedependent (P < 0.0001). There was no significant differences between the performance of black and green tea (P > 0.05). Conclusion: Black and green tea extracts demonstrated the potential to inhibit the Acanthamoeba parasite, but the use of tea extract in clinical applications requires further study.
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Keywords
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Acanthamoeba ,Camellia sinensis ,Black tea ,Green tea ,Complementary therapy ,Traditional medicine
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