Effects of Ginger on Spermatogenesis in Streptozotocin-induced Diabetic Rat

Background: ginger rhizome (zingiber officinale r., family: zingiberaceae) is usedmedicinally and as a culinary spice. the medicinal use of ginger dates back to ancientchina and india.objective: ginger and its constituents are stated to have antiemetic, antithrombotic,antihepatotoxic, anti-inflammatory, stimulant, cholagogue and antioxidant.enhancedoxidative stress and changes in antioxidant capacity are considered to play an importantrole in the pathogenesis of chronic diabetes mellitus.methods: wistar male rat (n=40) were allocated into three groups, control group (n=10)and ginger (g) group that received 100mg/kg-perday (oral), (n=10), and diabetic groupthat received 55 mg/kg (ip) streptozotocin (stz) (n=20) which was subdivided to twogroups of 10; stz group and treatment group. treatment group received 55mg/kg (ip)stz plus ginger 100mg/kg-perday (g), daily for, 4 weeks, respectively; however, thecontrol group just received an equal volume of distilled water daily(ip). diabetes wasinduced by a single (ip) injection of streptozotocin (55 mg/kg). animals were kept instandard condition. in 28day after inducing diabetic 5cc blood were collected for tac,mda and sperm parameters and testis tissues of rat in whole groups were removed thenprepared for analyzes.results:tac, mda and sperm parameters significantly decreased in diabeticgroup.treatment groub that has received ginger 100 mg/kg (oral) show increasing intac and sperm parameters (p<0.05) in comparison to experimental groups (p<0.05).conclusion: since in our study 100 mg/kg (oral) ginger have significantly preventiveeffect on sperm parameters, so it seems that using it can be effective for treatment indiabetic rat.