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Identification and partial purification of an anticoagulant factor from the venom of the Iranian snake Agkistrodon halys
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نویسنده
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ghorbanpur m. ,zare mirakabadi a. ,zokaee f. ,zolfagarrian h.
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منبع
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journal of venomous animals and toxins including tropical diseases - 2010 - دوره : 16 - شماره : 1 - صفحه:96 -106
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چکیده
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An anticoagulant factor was purified from the venom of the iranian snake agkistrodon halys by gel filtration on sephadex g-50 and ion-exchange chromatography on deae-sepharose. in the final stage of purification,the percentage recovery of purified anticoagulant factor was found to be 83%. the purified anticoagulant factor revealed a single protein band in sds-polyacrylamide electrophoresis under reducing conditions and its molecular weight was about 22 kda. the purified peptide did not show any effect on casein,bapna or plasma.
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کلیدواژه
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Agkistrodon halys; Anticoagulant factor; Chromatography; Snake venom
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آدرس
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chemical engineering department,amirkabir university,tehran, ایران, department of venomous animals and antivenom production,razi vaccine and serum research institute,karaj, ایران, chemical engineering department,amirkabir university,tehran, ایران, department of venomous animals and antivenom production,razi vaccine and serum research institute,karaj, ایران
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Authors
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