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   In vivo pharmacological study on the effectiveness of available polyclonal antivenom against hemiscorpius lepturus venom  
   
نویسنده jalali a. ,pipelzadeh m.h. ,seyedian r. ,rahmani a.h. ,omidian n.
منبع journal of venomous animals and toxins including tropical diseases - 2011 - دوره : 17 - شماره : 2 - صفحه:142 -149
چکیده    The available razi institute antivenom is still,empirically,used by intramuscular (im) administration for the treatment of scorpion stings in humans by six medically dangerous species including hemiscorpius lepturus (h. lepturus). the aim of this study was to assess the neutralizing ability and effectiveness of the antivenom in inhibiting hemoglobinuria,biochemical changes,increased microalbuminuria and urinary lactate dehydrogenase (ldh) following h. lepturus sting. simultaneous intramuscular administration of 10 μl and 100 μl of antivenom,after 24 hours,had no significant preventive effect on the extent and degree of hemoglobinuria or proteinuria produced in venom-treated rats. after im administration of antivenom,no significant changes in decreased red blood cell (rbc) count and hemoglobin were observed. immediate intramuscular administration of 10 μl of antivenom had no significant effects on both ldh and microalbuminuria. the present findings did not present correlation with clinical signs. therefore,to fully assess the efficacy of the available antivenom and make appropriate recommendations,more in vivo or in vitro investigations including antigen-antibody interaction,enzymatic analysis and route-dependent administration are required. © cevap 2011.
کلیدواژه Antivenom; Hemiscorpius lepturus; Hemolysis; Scorpion; Venom
آدرس department of pharmacology and toxicology,school of pharmacy,jundishapur university of medical sciences,ahvaz,iran,toxicology research center,jundishapur university of medical sciences,ahvaz, ایران, toxicology research center,jundishapur university of medical sciences,ahvaz,iran,department of pharmacology,school of medicine,jundishapur university of medical sciences,ahvaz, ایران, department of pharmacology and toxicology,university of medical sciences,bushehr, ایران, department of internal medicine,razi hospital,jundishapur university of medical sciences,ahvaz, ایران, faculty of veterinary medicine,chamran university,ahvaz, ایران
 
     
   
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