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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA): Molecular background,virulence,and relevance for public health
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نویسنده
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bonesso m.f. ,marques s.a. ,cunha m.l.r.s.
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منبع
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journal of venomous animals and toxins including tropical diseases - 2011 - دوره : 17 - شماره : 4 - صفحه:378 -386
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چکیده
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Staphylococcus aureus and coagulase-negative staphylococcus (cons) are frequently found in nosocomial environments as the main pathogen in several infections. in 1961,reports of nosocomial s. aureus resistant to methicillin,the drug of choice against penicillin-resistant strains,required new alternatives and vancomycin started being used to treat infections caused by methicillin-resistant s. aureus (mrsa). community-acquired methicillin-resistant s. aureus (ca-mrsa) was first reported in 1990 affecting patients without risk factors for infection with mrsa of hospital origin. mrsa of community origin harbor the genes responsible for the synthesis of panton-valentine leukocidin (pvl),a toxin associated with skin and soft tissue infections and that carries the staphylococcal cassette chromosome mec (sccmec) type iv. ca-mrsa emergence has caused great impact on the worldwide medical community since the presence of this pathogen in patients without risk factors represents a high risk to public health. © cevap 2011.
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کلیدواژه
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Drug resistance; Epidemiology; MecA gene; Methicillin-resistant staphylococcus aureus; Oxacillin; Panton-valentine leukocidin
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آدرس
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department of microbiology and immunology,botucatu biosciences institute,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state,brazil,department of tropical diseases,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil, departament of dermatology e radiotherapy,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil, department of microbiology and immunology,botucatu biosciences institute,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil
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Authors
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