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DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
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نویسنده
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barbosa a.s.a.a. ,de oliveira l.r.c. ,tavares f.c. ,de lima c.r.g. ,diório s.m. ,calvi s.a. ,vilani-moreno f.r. ,pereira p.c.m.
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منبع
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journal of venomous animals and toxins including tropical diseases - 2015 - دوره : 21 - شماره : 1
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چکیده
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Background: jorge lobo's disease,also known as lacaziosis,is a cutaneous-subcutaneous mycosis with chronic evolution. it is caused by the funguslacazia loboi. herein we report a study that relates the genotoxicity caused by l. loboiin isogenic mice with nutritional status,through a normal or restricted diet. methods: dna damage was assessed in the peripheral blood by the comet assay (tail intensity). results: the results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction,in infected mice under dietary restriction and in infected mice ingesting a normal diet. conclusion: these results indicate that dietary restriction and l. loboiinfection may increase dna damage levels in mice,as detected by the comet assay. © 2015 barbosa et al.
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کلیدواژه
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Comet assay; Genotoxicity; Jorge Lobo' disease; Lacazia loboi; Malnutrition; Mice
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آدرس
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biology technical team,lauro de souza lima institute,bauru,são paulo state,brazil,equipe técnica de biologia,instituto lauro de souza lima,rod. comte. joão ribeiro de barros,km 225/226,bauru,sp,cep 17.034-971, Brazil, department of tropical diseases and image diagnosis,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil, department of tropical diseases and image diagnosis,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil, department of tropical diseases and image diagnosis,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil, microbiology technical team,lauro de souza lima institute,bauru,são paulo state, Brazil, department of tropical diseases and image diagnosis,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil, biology technical team,lauro de souza lima institute,bauru,são paulo state, Brazil, department of tropical diseases and image diagnosis,botucatu medical school,são paulo state university (unesp - univ estadual paulista),botucatu,são paulo state, Brazil
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Authors
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