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   In the picture: Disulfide-poor conopeptides,a class of pharmacologically interesting compounds  
   
نویسنده lebbe e.k.m. ,tytgat j.
منبع journal of venomous animals and toxins including tropical diseases - 2016 - دوره : 22 - شماره : 1
چکیده    During evolution,nature has embraced different strategies for species to survive. one strategy,applied by predators as diverse as snakes,scorpions,sea anemones and cone snails,is using venom to immobilize or kill a prey. this venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. these venom peptides,called conopeptides,are classified into two main groups based on the number of cysteine residues,namely disulfide-rich and disulfide-poor conopeptides. since disulfide-poor conotoxins are minor components of this venom cocktail,the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. this review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs. © 2016 the author(s).
کلیدواژه Conantokin; Cone snail; Cono-NPY; ConoCAP; ConoGAY; Conolysin; Conomap; Conomarphin; Conophan; Conopressin; Conorfamid; Contryphan; Contulakin
آدرس ku leuven,o and n2,toxicology and pharmacology,herestraat 49,box 922,leuven,3000, Belgium, ku leuven,o and n2,toxicology and pharmacology,herestraat 49,box 922,leuven,3000, Belgium
 
     
   
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