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Multiple uses of fibrin sealant for nervous system treatment following injury and disease
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نویسنده
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biscola n.p. ,cartarozzi l.p. ,ulian-benitez s. ,barbizan r. ,castro m.v. ,spejo a.b. ,ferreira r.s. ,barraviera b. ,oliveira a.l.r.
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منبع
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journal of venomous animals and toxins including tropical diseases - 2017 - دوره : 23 - شماره : 1
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چکیده
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Lesions to the nervous system often produce hemorrhage and tissue loss that are difficult,if not impossible,to repair. therefore,scar formation,inflammation and cavitation take place,expanding the lesion epicenter. this significantly worsens the patient conditions and impairment,increasing neuronal loss and glial reaction,which in turn further decreases the chances of a positive outcome. the possibility of using hemostatic substances that also function as a scaffold,such as the fibrin sealant,reduces surgical time and improve postoperative recovery. to date,several studies have demonstrated that human blood derived fibrin sealant produces positive effects in different interventions,becoming an efficient alternative to suturing. to provide an alternative to homologous fibrin sealants,the center for the study of venoms and venomous animals (cevap,brazil) has proposed a new bioproduct composed of certified animal components,including a thrombin-like enzyme obtained from snake venom and bubaline fibrinogen. thus,the present review brings up to date literature assessment on the use of fibrin sealant for nervous system repair and positions the new heterologous bioproduct from cevap as an alternative to the commercial counterparts. in this way,clinical and pre-clinical data are discussed in different topics,ranging from central nervous system to peripheral nervous system applications,specifying positive results as well as future enhancements that are necessary for improving the use of fibrin sealant therapy. © 2017 the author(s).
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کلیدواژه
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Central nervous system; Commercial fibrin sealant; Fibrin tissue adhesive; Nervous system injury; New heterologous fibrin sealant; Peripheral nervous system
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آدرس
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univ estadual paulista (unesp),graduate program in tropical diseases,botucatu medical school,botucatu,sp,brazil,univ estadual paulista (unesp),center for the study of venoms and venomous animals (cevap),botucatu,sp,brazil,university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970, Brazil, university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970, Brazil, university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970,brazil,university of birmingham,neuro development lab,school of biosciences,birmingham,england, United Kingdom, university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970,brazil,federal university of jequitinhonha and mucuri valleys (ufvjm),the school of medicine at mucuri (fammuc),teófilo otoni,mg,39803-371, Brazil, university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970, Brazil, university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970, Brazil, jr.,univ estadual paulista (unesp),graduate program in tropical diseases,botucatu medical school,botucatu,sp,brazil,univ estadual paulista (unesp),center for the study of venoms and venomous animals (cevap),botucatu,sp, Brazil, univ estadual paulista (unesp),graduate program in tropical diseases,botucatu medical school,botucatu,sp,brazil,univ estadual paulista (unesp),center for the study of venoms and venomous animals (cevap),botucatu,sp, Brazil, university of campinas (unicamp),laboratory of nerve regeneration,department of structural and functional biology,institute of biology,campinas,sp,13083-970, Brazil
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Authors
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