Interleukin 8 (-251T>A) polymorphism in children and teenagers infected with Helicobacter pylori

Background: helicobacter pylori (h. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. this study evaluated the correlations between the -251 (t>a) (rs4073) polymorphism of interleukin-8 (il-8),the etiology of gastric disease,and h. pylori infection in pediatric and adolescent patients. methods: dna samples were obtained from 285 gastric biopsies from pediatric patients. h. pylori was detected by pcr,whereas pcr-rflp was used to characterize the -251 (t>a) polymorphism of il-8. results: the histological analysis revealed the presence of gastritis in 158 patients (55.44%). h. pylori was found in 71 samples (24.9%). the -251 (t>a) polymorphism revealed that 58 (29.47%) samples were tt,143 (50.18%) samples were ta,and 84 (20.35%) samples were aa. conclusions: our findings suggest that il8-251 a allele may be an important risk factor for the development of gastric disease when associated with h. pylori infection. © 2017 the author(s).