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Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
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نویسنده
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Hussin Mahanom ,Abd. Hamid Azizah ,Mohamed Suhaila ,Saari Nazamid ,Ismail Maznah ,Bejo Mohd. Hair
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منبع
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journal of tropical agriculture and food science - 2011 - دوره : 39 - شماره : 1 - صفحه:45 -54
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چکیده
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A study was conducted to investigate the effect of centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (h2o2)-treated male sprague-dawley rats. the experimental rats were fed with 0.3% (w/w) c. asiatica extract, 1.5% (w/w) c. asiatica powder, 5.0% (w/w) c. asiatica powder and 0.3% (w/w) a-tocopherol for 6 weeks. to induce oxidative stress, the rats were given drinking water spiked with 0.03% (v/v) h2o2. the amount of dietary intake, organ and body weight, and malonaldehyde (mda) level throughout the study were monitored. histopathological examination of selected organs was done at the end of the study. the results showed that mda level was significantly (p <0.05) higher in the normal rats compared to treated rats. dietary supplementation of c. asiatica (extract and powder) and a-tocopherol significantly (p <0.05) reduced lipid peroxidation in the experimental rats. however, there were no significant differences in dietary intake and histopathology observations of the organs of the rats
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کلیدواژه
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Centella asiatica ,lipid peroxidation ,malonaldehyde ,hydrogen peroxide ,Sprague-Dawley rats
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آدرس
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MARDI Headquarters, Food Technology Research Centre, Malaysia, Universiti Putra Malaysia, Faculty of Food Science and Technology, Depanment of Food Science, Malaysia, Universiti Putra Malaysia, Faculty of Food Science and Technology, Department of Food Science, Malaysia, Universiti Putra Malaysia, Faculty of Food Science and Technology, Depanment of Food Science, Malaysia, Universiti Putra Malaysia, Institute of Bioscience, Laboratory of Molecular Biomedicine, Malaysia, Universiti Putra Malaysia, Faculty of Veterinary Medicine, Department of Veterinary, Pathology and Microbiology, Malaysia
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پست الکترونیکی
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mahanom@mardi.gov.my
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Authors
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