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   use of an extended inr follow-up interval for veteran patients in an anticoagulation clinic  
   
نویسنده porter andrea l. ,margolis amanda r. ,schoen rebecca r. ,staresinic carla e. ,ray cheryl a. ,fletcher christopher d.
منبع journal of thrombosis and thrombolysis - 2017 - دوره : 43 - شماره : 3 - صفحه:318 -325
چکیده    A prospective, single-arm study of 50 participants evaluated an extended inr follow-up interval to determine the implementation feasibility and safety of an extended interval in veterans on a stable dose of warfarin. a protocol was designed to allow for a rigorous, yet pragmatic evaluation of a 12-week inr follow-up interval. feasibility was determined by study enrollment, retention, and participant achievement rates for the extended inr interval. safety was determined by bleeding and thromboembolism rates. participants were monitored for 6 months. despite the long-term stability of participants prior to enrollment, only 56% achieved a 12-week follow-up interval and only 34% of enrolled participants maintained a 12-week interval. sixteen percent of participants were never eligible for an extension of their inr follow-up interval despite meeting initial enrollment criteria. there were two major bleeding events and one participant who experienced a thromboembolic event. implementation of an extended interval of inr follow-up appears feasible as participant enrollment goals were met and pharmacists were able to follow the study protocol. however, a lower than expected proportion of participants were able to achieve and maintain an extended inr follow-up interval. future evaluations are needed to confirm the safety of an extended inr interval.
کلیدواژه anticoagulation ,warfarin ,interval ,monitoring ,international normalized ratio (inr) ,management
آدرس university of wisconsin-madison school of pharmacy, usa. william s. middleton memorial veterans hospital, usa, university of wisconsin-madison school of pharmacy, usa. william s. middleton memorial veterans hospital, usa, william s. middleton memorial veterans hospital, usa, william s. middleton memorial veterans hospital, usa, william s. middleton memorial veterans hospital, usa, william s. middleton memorial veterans hospital, usa
 
     
   
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