cerebral venous sinus thrombosis complicated by seizures: a retrospective analysis of 69 cases

Cerebral venous sinus thrombosis (cvst) is a rare ischemic cerebrovascular disease. the aim of this retrospective observational study was to investigate the risk factors for complication of cerebral venous sinus thrombosis by seizures and to explore the impact of such seizures on clinical outcomes. patients with cerebral venous sinus thrombosis with or without epileptic seizures were retrospectively analyzed and compared in terms of clinical variables, causative factors, clinical presentation, and imaging data. in all, 69 patients with cerebral venous sinus thrombosis were enrolled in this study, 32 (46.38%) of whom had experienced secondary seizures. compared with those with no seizures, significantly more patients with secondary seizures had hemiplegia (37.50 vs. 15.63%; p = 0.020), bleeding (29.40 vs. 10.81%; p = 0.047), lesions involving the frontal (31.25 vs. 10.81%; p = 0.023) and temporal lobe (43.75 vs. 8.11%; p = 0.005), and thrombosis in the superior sagittal sinus (65.63 vs. 40.54%; p = 0.036). multivariate logistic regression analysis showed focal neurological deficits (p = 0.004, odds ratio = 5.16, 95% ci 1.99–15.76) and thrombosis of the superior sagittal sinus (p = 0.039, odds ratio = 0.13, 95% ci 0.04–0.37) were independent risk factors for secondary seizures in patients with cerebral venous sinus thrombosis. in addition, mortality rate (9.38 vs. 5.41%; p = 0.469) and 90-day excellent prognosis rate (81.25 vs. 86.47%; p = 0.793) did not differ significantly between patients with and without epileptic seizures. the presence of focal neurological deficits and thrombosis of the superior sagittal sinus are independent risk factors for secondary seizures in patients with cerebral venous sinus thrombosis, whereas mortality and 90-day prognosis have no correlation with secondary seizures.