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association study of mir-146a, mir-149, mir-196a2, and mir-499 polymorphisms with venous thromboembolism in a korean population
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نویسنده
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kim jung oh ,kim hyun woo ,an hui jeong ,kim ok joon ,oh jisu ,chong so young ,choi won-il ,oh doyeun ,kim nam keun
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منبع
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journal of thrombosis and thrombolysis - 2019 - دوره : 47 - شماره : 2 - صفحه:255 -262
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چکیده
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Despite much progress in microrna (mirna) research, information regarding the association between mirnas and venous thromboembolism (vte), especially in asian patients, remains limited. this case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the mirnas mir-146a, mir-149, mir-196a2, mir-499, and vte in korean patients. we observed no statistically significant differences in the genotype frequency of mirna polymorphisms between 300 control individuals and 203 vte patients. however, we observed a significant association between three allelic combinations of mirna polymorphisms and vte risk. overall, our findings suggest that specific mirna polymorphisms are associated with the risk of vte in a korean population.
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کلیدواژه
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deep vein thrombosis ,microrna ,single nucleotide polymorphism ,pulmonary embolism
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آدرس
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cha university, college of life science, department of biomedical science, south korea, cha university, college of life science, department of biomedical science, south korea, cha university, college of life science, department of biomedical science, south korea, cha university, cha bundang medical center, school of medicine, department of neurology, south korea, cha university, cha bundang medical center, department of internal medicine, south korea, cha university, cha bundang medical center, department of internal medicine, south korea, keimyung university school of medicine, keimyung university dongsan medical center, department of internal medicine, south korea, cha university, cha bundang medical center, department of internal medicine, south korea, cha university, college of life science, department of biomedical science, south korea
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Authors
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